• Document: Biosynthesis of Zinc oxide Nanoparticles using Melia azedarach L. extracts and their Characterization
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International Journal of Pharmaceutical Science and Research ISSN: 2455-4685 www.pharmacyresearchjournal.com Volume 1; Issue 1; January 2016; Page No. 31-36 Biosynthesis of Zinc oxide Nanoparticles using Melia azedarach L. extracts and their Characterization Manokari M, Ravindran C.P, Mahipal S Shekhawat Biotechnology Laboratory, Department of Plant Science, M.G.G.A.C, Mahe, Pondicherry, India Abstract The present study focuses on the bioproduction of Zinc oxide nanoparticles (ZnO NPs) from the aqueous extracts of leaves, stem, roots, flowers and fruits of Melia azedarach L. The plant is enriched with alkaloids, sterols, glycosides, phenolic compounds, tannins, flavonoids, saponins and other biologically active phytocompounds. Zinc Nitrate hexahydrate [Zn (NO3)2.6H2O] was used as precursor to synthesize ZnO nanoparticles. UV- Visible spectral studies were conducted for the characterization and confirmation of the synthesized ZnO nanoparticles. It showed that the test solutions had strong absorbance in the range of 290-330 nm. Hence the biogenic synthesis of ZnO nanoparticles using M. azedarach could be explored in various fields. Keywords: Melia azedarach, Zinc oxide nanoparticles, UV-Visible spectral analysis, characterization. 1. Introduction biological methods [12]. Recently, synthesis of metallic Nanotechnology has a great potential to modify conventional nanoparticles using plant extracts is proved to be non- agricultural practices [1]. It could have a dominant position in hazardous and getting more popular [13]. Green synthesis of transforming agriculture and food production. The nanoparticles includes the use of ecofriendly plant materials bioprocessing mediated nanotechnology converts the and safe solvents like water and natural extracts [14]. Plants are agricultural and food wastes into energy and useful by- the largest source of herbal medicine since the ancient ages as products [2]. Metal oxide nanoparticles are reported to play traditional health care system. The bioactive phytochemical important role to promote the growth and yield of plants [3]. constituents of plants are the base of modern drugs as well as Biosynthesized metallic nanoparticles from plant derivatives conventional medicinal systems that are being still in use. are used in medical and commercial sectors including waste Melia azedarach L. is popularly known as Indian lilac or water treatment, cosmetics and food industry. Recently, the Persian lilac. It belongs to the family Meliaceae and native to plant mediated nanoparticles synthesis has drawn more India, Indochina, Southeast Asia and Australia. This plant is attention due to its vast application in various fields due to their naturalized in most of the tropics and subtropical countries. In physic-chemical properties. Zinc oxide nanoparticles (ZnO India it is widely distributed in Himalayan region between the NPs) were synthesized from natural resources and have been altitudes of 700 to 1000 m. The plant is characterized by the studied exclusively. Zinc oxides are multifunctional material presence of dense and dark green leaves. Its bark is dark brown with its unique physical and chemical properties. ZnO in color and fissured. The leaves are alternate, leaflets are short nanoparticles were more abrasive than bulk ZnO (particle sizes stalked. Flowers are white with purple stripes and in the range of 0.1-1 μm) [4]. characterized by the presence of a typical fragrance. Fruits are ZnO nanoparticles are used in medicine field because of their yellow berries, smooth and fleshy [15]. site specific mechanical damage to the bacterial cell membrane The phytochemical composition of M. azedarach is relatively and the enhanced bactericidal effect [5]. ZnO semiconductors complete. It is endowed with alkaloids, sterols, glycosides, have been extensively studied due to their photocatalytic fixed oil and fats, phenolic compounds, tannins, flavonoids, activity under UV light [6]. These nano antimicrobial saponins, gum and mucilages, triterpenes, limonoids, substances based on phytochemicals have been found to be azadirachitin, nimbin, nimbidin, gedunin, melianoninol, effective for safe therapeutic properties [7]. Many researchers melianol, melianone, meliandiol, vanillin, nimbinene, have attempted to prove the biological properties of ZnO meliacin, quercertin and rutin [15-20]. nanoparticles. Their targeting potential has utility in the Traditionally it has been used in the treatment of leprosy, treatment of cancer and autoimmunity [8]. The colloidal inflammations, cardiac disorders, malaria, diabetes, cough, solution of Zinc oxide na

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