• Document: The Role of Viral Glycoproteins and Tegument Proteins in Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment
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Louisiana State University LSU Digital Commons LSU Doctoral Dissertations Graduate School 2014 The Role of Viral Glycoproteins and Tegument Proteins in Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment Dmitry Vladimirovich Chouljenko Louisiana State University and Agricultural and Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_dissertations Part of the Veterinary Pathology and Pathobiology Commons Recommended Citation Chouljenko, Dmitry Vladimirovich, "The Role of Viral Glycoproteins and Tegument Proteins in Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment" (2014). LSU Doctoral Dissertations. 4076. https://digitalcommons.lsu.edu/gradschool_dissertations/4076 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Doctoral Dissertations by an authorized graduate school editor of LSU Digital Commons. For more information, please contactgradetd@lsu.edu. THE ROLE OF VIRAL GLYCOPROTEINS AND TEGUMENT PROTEINS IN HERPES SIMPLEX VIRUS TYPE 1 CYTOPLASMIC VIRION ENVELOPMENT A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Interdepartmental Program in Veterinary Medical Sciences through the Department of Pathobiological Sciences by Dmitry V. Chouljenko B.Sc., Louisiana State University, 2006 August 2014 ACKNOWLEDGMENTS First and foremost, I would like to thank my parents for their unwavering support and for helping to cultivate in me from an early age a curiosity about the natural world that would directly lead to my interest in science. I would like to express my gratitude to all of the current and former members of the Kousoulas laboratory who provided valuable advice and insights during my tenure here, as well as the members of GeneLab for their assistance in DNA sequencing. I would like to thank the faculty members that served on my graduate committee, Dr. Shafiqul I. Chowdhury, Dr. Masami Yoshimura, Dr. Bret D. Elderd and Dr. Inder Sehgal for their guidance. Most of all, I would like to thank my mentor, Dr. Konstantin G. Kousoulas, for the tremendous amount of support, patience and guidance he has provided during my journey to graduation. ii TABLE OF CONTENTS ACKNOWLEDGMENTS ...................................................................................................................... ii LIST OF TABLES ................................................................................................................................ vi LIST OF FIGURES ............................................................................................................................. vii ABSTRACT ........................................................................................................................................ ix CHAPTER I: INTRODUCTION ............................................................................................................ 1 Statement of Problem and Hypothesis............................................................................... 1 Statement of Research Objectives...................................................................................... 2 CHAPTER II: LITERATURE REVIEW ................................................................................................... 6 History of Herpes ................................................................................................................ 6 Taxonomy of Herpesviruses.............................................................................................. 10 Herpesviral Disease ........................................................................................................... 17 Herpes simplex viruses (HHV-1 and HHV-2) ......................................................... 18 Varicella-zoster virus (HHV-3) ............................................................................... 23 Cytomegalovirus (HHV-5)...................................................................................... 23 Kaposi’s sarcoma-associated herpesvirus (HHV-8)............................................... 24 Human herpes

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