• Document: World Journal of Pharmaceutical Research
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World Journal of Pharmaceutical research Bambal et al. World Journal of Pharmaceutical Research Volume 3, Issue 2, 3026-3035. Research Article ISSN 2277 – 7105 EVALUATION OF IN VITRO SUNSCREEN ACTIVITY OF HERBAL CREAM CONTAINING EXTRACT OF CURCUMA LONGA AND BUTEA MONOSPERMA Vaishali Bambal*1 and Manisha Mishra2 1 Dhanvanthri College of Pharmaceutical Sciences, Mahabubnagar, (A.P.) 2 Manoharbhai Patel Institute of Pharmacy, Gondia (M.S.) Article Received on ABSTRACT 05 January 2014, The aim of the present study was to evaluate the in vitro sunscreen Revised on 25 January 2014, Accepted on 27 February activity of Herbal cream containing rhizome extract of Curcuma 2014 longa Linn. (Fam. Zingiberaceae) and flower extract of Butea monosperma Lam. (Fabaceae). The dried powdered rhizomes and *Correspondence for Author flowers were extracted successively with petroleum ether and Vaishali Bambal ethanol in soxhlet apparatus. Two sunscreen creams were Dhanvanthri College of Pharmaceutical Sciences, formulated using ethanolic extract and tested for the Mahabubnagar, (A.P.). physicochemical parameters such as colour, odour, spreadability, pH, specific gravity, limit test for lead and viscosity. Stability study and sensitivity study was done by centrifugation method and patch test for irritancy respectively. The in vitro SPF of the formulations was determined according to the UV Spectrophotometric method of Mansur et al. The sunscreen cream containing ethanolic extract of Curcuma longa under study produced high absorbance at 290-320 nm wavelength range and SPF obtained was 12.08 ± 4.44, where as for Butea monosperma sunscreen cream it was 10.21±1.13. From the result obtained in the study, we can positively conclude that Curcuma longa sunscreens significantly contribute in the preparation of photoprotective cosmetic formulations which could prevent the skin with harmful effects of ultraviolet radiations. It will also help in broadening the UV protection ability of the sunscreen along with the greatest advantage of avoiding the adverse and undesired effects of synthetic sunscreen compounds. KEYWORDS: Butea monosperma, Curcuma longa, sun protection factor (SPF). www.wjpr.net Vol 3, Issue 2, 2014. 3026 Bambal et al. World Journal of Pharmaceutical Research INTRODUCTION The rapid growth of commercially available products containing sunscreens indicates that even though a suntan is still desired people are conscious of the possible dangers of photo- ageing and skin cancer, occurring as a result of sun overexposure. The harmful effects of solar radiation are caused predominantly by the ultraviolet (UV) region of electromagnetic spectrum, which can be divided into three regions: UVA, from 320 nm to 400nm, UVB, from 290 nm to 320 nm and UVC, from 200 nm to 290 nm. UVC radiation is filtered out by the ozone layer and is responsible for the damage due to sunburn.[1] UVA radiation reaches the deeper layer of epidermis and dermis and provokes the premature ageing of the skin. [2] Ultraviolet radiations have been implicated as a causative factor of skin cancer. The efficacy of sunscreen is usually expressed by the sun protection factor (SPF), which is defined as the UV energy required for producing a minimal erythema dose (MED) on protected skin, divided by the UV energy required for producing a MED on unprotected skin. Minimal erythema dose in sunscreen protected skin SPF = ----------------------------------------------------------------------------- Minimal erythema dose in non-sunscreen protected skin The minimal erythema dose (MED) is defined as the lowest time interval or dosage of UV light radiation sufficient to produce a minimal, perceptible erythema on unprotected skin. [3,4] Although modern sunscreen containing UV filters are highly efficient to protect the skin from deleterious effects of the sun, but herbal sunscreens are rapidly replacing them due to associated side effects with UV filters. So many herbal sunscreens are available in market in the form of creams, lotions and gels having labeled sun protection factor. Most commonly used herbs are aloe Vera, bas

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